Investigation of brain circuits underlying compulsive behaviour in opiate dependence

Drug addiction is a major public health issue, characterised by intense cravings and compulsive drug-taking. This apparent loss of control over drug intake, even in the face of adverse consequences (eg, health, relationships, finances, legal problems etc), suggests that some addicts have problems making decisions, such that they are unable to inhibit the strong urges associated with exposure to drugs and related paraphernalia. This project utilises brain imaging, psychophysiology and neurocognitive tests to assess the brain’s processing of natural rewards and drug cues, as well as the integrity of the brain’s inhibitory system in opiate addiction. The relationship with ongoing drug use is also examined. Recruitment for the study has now been completed, and data analysis is underway.